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Article

Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

21 Aug 2025

Abstract excerpt

Histologic transformation of prostate cancer from adenocarcinoma to neuroendocrine prostate cancer (NEPC) is associated with aggressive disease and poor prognosis. This lineage transition is accompanied by polycomb complex 2-mediated epigenetic derepression of cell fate-determining transcription factors, including prospero homeobox 1 (PROX1). In this study, we sought to functionally characterize the role of PROX1...

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PMID: 40838977
DOI: 10.1158/0008-5472.can-25-0636

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