Article

Interpretable variational encoding of genotypes identifies comprehensive clonality and lineages in single cells geometrically

2024-07-09

Abstract excerpt

Clone assignment in single-cell genomics remains a challenge due to its diverse mutation macrostructures and many missing signals. Existing statistical methods, for the sake of numerical convergence, pose strong constraints on the form of predicted mutation patterns, so they easily identify sub-optimally fitted clones that overlook weak and rare mutations. To solve this problem, we developed SNPmanifold, a Python...

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Literature Corpus work: 69f34fe5-dee7-5140-853d-f28e142b490f
DOI: 10.1101/2024.07.04.602109

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