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Article

bmVAE: a variational autoencoder method for clustering single-cell mutation data.

Bioinformatics (Oxford, England) - 1 Jan 2023

Yan Jiaqian, Ma Ming, Yu Zhenhua

Abstract excerpt

MOTIVATION: Genetic intra-tumor heterogeneity (ITH) characterizes the differences in genomic variations between tumor clones, and accurately unmasking ITH is important for personalized cancer therapy. Single-cell DNA sequencing now emerges as a powerful means for deciphering underlying ITH based on point mutations of single cells. However, detecting tumor clones from single-cell mutation data remains challenging...

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Identifiers

PMID: 36478203
DOI: 10.1093/bioinformatics/btac790
PMCID: PMC9825778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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