Article

Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

2005-01-20

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathogenic autoantibodies against nucleoproteins and DNA. Here we show that DNA-containing immune complexes (ICs) within lupus serum (SLE-ICs), but not protein-containing ICs from other autoimmune rheumatic diseases, stimulates plasmacytoid DCs (PDCs) to produce cytokines and chemokines via a cooperative interaction between Toll-like rece...

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Identifiers and source

Literature Corpus work: 69dd105b-8cf2-5d77-871d-97b747cae634
DOI: 10.1172/jci200523025

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