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Article

DNA-dependent Activator of Interferon-regulatory Factors (DAI) Promotes Lupus Nephritis by Activating the Calcium Pathway

4 Apr 2013

Abstract excerpt

BACKGROUND: Macrophage M2b polarization conferred by self-DNA immunization initiates and propagates lupus nephritis. RESULTS: Knockdown of DNA-dependent activator of interferon-regulatory factors (DAI) ameliorates SLE syndrome via blunting macrophage M2b polarization. CONCLUSION: DAI functions as a DNA sensor in self-DNA-induced macrophage M2b polarization and lupus nephritis. SIGNIFICANCE: We disclose the...

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Identifiers

PMID: 23553627
DOI: 10.1074/jbc.m113.457218

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