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Article

Toll‐Like Receptor Activation in the Pathogenesis of Systemic Lupus Erythematosus

1 Dec 2005

Abstract excerpt

Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies to nucleoproteins and DNA. The level of anti-DNA antibodies correlates with disease severity, and the deposition of these immune complexes (ICs) in the kidneys is thought to contribute to disease pathogenesis. Recent evidence suggests that the DNA component of ICs purified from SLE patients (SLE DNA-ICs) contributes...

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PMID: 16461805
DOI: 10.1196/annals.1358.027

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