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Article

Mechanisms of Autoantibody Production in Systemic Lupus Erythematosus

13 May 2015

Abstract excerpt

Autoantibodies against a panoply of self-antigens are seen in systemic lupus erythematosus, but only a few (anti-Sm/RNP, anti-Ro/La, anti-dsDNA) are common. The common lupus autoantigens are nucleic acid complexes and levels of autoantibodies can be extraordinarily high. We explore why that is the case. Lupus is associated with impaired central or peripheral B-cell tolerance and increased circulating autoreactive...

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PMID: 26029213
DOI: 10.3389/fimmu.2015.00228

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