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Article

A Toll for lupus

1 Jun 2005

Abstract excerpt

Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is...

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PMID: 16038103
DOI: 10.1191/0961203305lu2102rr

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