Article
The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope.
Communications biology - 28 Jul 2022
Miglioranza Scavuzzi Bruna, van Drongelen Vincent, Kaur Bhavneet, Fox Jennifer Callahan, Liu Jianhua, Mesquita-Ferrari Raquel A, Kahlenberg J Michelle, Farkash Evan A, Benavides Fernando, Miller Frederick W, Sawalha Amr H, Holoshitz Joseph
Abstract excerpt
The HLA-DRB1*03:01 allele is a major genetic risk factor in systemic lupus erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show that in the presence of interferon gamma (IFN-γ), a short DRB1*03:01-encoded allelic epitope activates a characteristic lupus transcriptome in mouse and human macrophages. It also triggers a cascade of SLE-associated cellular aberrations, including...
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