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Article

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Aug 2010

Xu Ya-Fei, Gendron Tania F, Zhang Yong-Jie, Lin Wen-Lang, D'Alton Simon, Sheng Hong, Casey Monica Castanedes, Tong Jimei, Knight Joshua, Yu Xin, Rademakers Rosa, Boylan Kevin, Hutton Mike, McGowan Eileen, Dickson Dennis W, Lewis Jada, Petrucelli Leonard

Abstract excerpt

Transactivation response DNA-binding protein 43 (TDP-43) is a principal component of ubiquitinated inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions and in amyotrophic lateral sclerosis (ALS). Mutations in TARDBP, the gene encoding TDP-43, are associated with sporadic and familial ALS, yet multiple neurodegenerative diseases exhibit TDP-43 pathology without known TARDBP mutations....

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Identifiers

PMID: 20702714
DOI: 10.1523/JNEUROSCI.1630-10.2010
PMCID: PMC3056148

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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