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Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

14 Jun 2018

Abstract excerpt

Initial studies have found some evidence for transactive response DNA-binding protein 43 (TDP-43) abnormalities after traumatic brain injury (TBI), and the presence of protein inclusions consisting of TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis (ALS), a condition associated with TBI. However, no study has characterized changes in TDP-43 phosphorylation, mislocalization, and fragmentation...

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PMID: 29901412
DOI: 10.1089/neu.2017.5491

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