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The RIDD activity of <i>C. elegans</i> IRE1 modifies neuroendocrine signaling in anticipation of environment stress to ensure survival

2023-08-12

Abstract excerpt

Xbp1 splicing and regulated IRE1-dependent RNA decay (RIDD) are two RNase activities of the ER stress sensor IRE1. While Xbp1 splicing has important roles in stress responses and animal physiology, the physiological role(s) of RIDD remain enigmatic. Genetic evidence in C. elegans connects XBP1-independent IRE1 activity to organismal stress adaptation, but whether this is via RIDD, and what are the targets is yet...

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Literature Corpus work
69c0e1f4-11fc-5cb7-b298-c433de336b52
DOI
10.1101/2023.08.10.552841
Open publication

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The RIDD activity of <i>C. elegans</i> IRE1 modifies neuroendocrine signaling in anticipation of environment stress to ensure survivalDOI 10.1101/2023.08.10.552841
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