Article

Reprograming gene expression in “hibernating” <i>C. elegans</i> involves the IRE-1/XBP-1 pathway

2024-07-19

Abstract excerpt

<h4>ABSTRACT</h4> In nature, many animals respond to cold by entering hibernation, while in clinical settings, controlled cooling is used in transplantation and emergency medicine. However, the molecular mechanisms that enable cells to survive severe cold are still not fully understood. One key aspect of cold adaptation is the global downregulation of protein synthesis. Studying it in the nematode Caenorhabditis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54bf3854-f712-5c6a-9506-7b100df97c73
DOI: 10.1101/2024.07.16.603818

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reprograming gene expression in “hibernating” <i>C. elegans</i> involves the IRE-1/XBP-1 pathwayDOI 10.1101/2024.07.16.603818Read

The RIDD activity of <i>C. elegans</i> IRE1 modifies neuroendocrine signaling in anticipation of environment stress to ensure survivalSemantic proximity Read

Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolismSemantic proximity Read

Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.Semantic proximity Read

To be or not to be: the regulation of mRNA fate as a survival strategy during mammalian hibernation.Semantic proximity Read

Recent progress in the research of cold-inducible RNA-binding proteinSemantic proximity Read

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.Semantic proximity Read

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.Semantic proximity Read

Long-term recovery from acute cold shock in Caenorhabditis elegans.Semantic proximity Read

PEK-1 is crucial for hormesis induced by inhibition of the IRE-1/XBP-1 pathway in the Caenorhabditis elegans mev-1 mutant.Semantic proximity Read

A family of RRM-1 RNA binding proteins enables cold adaptation and environmental resilience in <i>Bacteroides</i>Semantic proximity Read

Transcriptome dynamics predict thermotolerance in <i>Caenorhabditis elegans</i>Semantic proximity Read

The unfolded protein response of the endoplasmic reticulum protects <i>Caenorhabditis elegans</i> against DNA damage caused by stalled replication forksSemantic proximity Read