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Article

Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons.

PLoS genetics - 1 Sept 2020

Guan Liying, Zhan Zhigao, Yang Yongzhi, Miao Yue, Huang Xun, Ding Mei

Abstract excerpt

ER stress occurs in many physiological and pathological conditions. However, how chronic ER stress is alleviated in specific cells in an intact organism is an outstanding question. Here, overexpressing the gap junction protein UNC-9 (Uncoordinated) in C. elegans neurons triggers the Ire1-Xbp1-mediated stress response in an age-dependent and cell-autonomous manner. The p38 MAPK PMK-3 regulates the chronic stress...

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Identifiers

PMID: 32986702
DOI: 10.1371/journal.pgen.1008704
PMCID: PMC7544145

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