Article

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies

2021-12-28

Abstract excerpt

Previous studies on the structural relationship between human antibodies and SARS-CoV-2 have focused on generating static snapshots of antibody complexes with the Spike trimer. However, antibody-antigen interactions are dynamic, with significant binding-induced allosteric effects on conformations of antibody and its target antigen. In this study, we employ hydrogen-deuterium exchange mass spectrometry, in vitro a...

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Identifiers and source

Literature Corpus work: 69bdb703-6e9e-55f9-aa46-a41df023641e
DOI: 10.1101/2021.12.27.474251

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