Article

Allostery links hACE2 binding, pan-variant neutralisation and helical extension in the SARS-CoV-2 Spike protein

2025-01-29

Abstract excerpt

The SARS-CoV-2 spike protein is highly antigenic, with epitopes in three distinct regions of the receptor binding domain (RBD) alone that have known mechanisms of neutralization. In previous work, we predicted a fourth RBD epitope based on allosteric conformational perturbations measured by hydrogen-deuterium exchange mass spectrometry (HDX-MS) upon complexation with the canonical spike protein target, human angio...

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Literature Corpus work: a1470132-7fe9-5310-8ac5-64f77993faa2
DOI: 10.1101/2025.01.28.635280

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Allostery links hACE2 binding, pan-variant neutralisation and helical extension in the SARS-CoV-2 Spike proteinDOI 10.1101/2025.01.28.635280Read

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