Article

Nintedanib and Pirfenidone Affect Growth and Differentiation of Human Alveolar Type 2 Cells

2026-03-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease characterized by epithelial cell senescence. Pirfenidone and nintedanib are approved drugs for the treatment of IPF. They significantly slow disease progression, but their mechanisms of action, especially on alveolar type 2 (AT2) cells, are poorly understood. We addressed this question by evaluating c...

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Literature Corpus work: 69b7cb63-161a-5c4e-b9ac-a2b6b08248fb
DOI: 10.64898/2026.03.02.708135

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