Article

Sub-stoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of a yeast prion protein

2021-03-09

Abstract excerpt

The prion-like self-perpetuating conformational conversion is involved in both transmissible neurodegenerative diseases and non-Mendelian inheritance traits. The transmissibility of amyloid-like aggregates is dependent on the stoichiometry of chaperones such as heat shock proteins. To provide the mechanistic underpinning of the generation and persistence of prefibrillar amyloid seeds that are critical for the prio...

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Literature Corpus work: cc3498e4-4fa4-55c8-93e1-abc7feaa0077
DOI: 10.1101/2021.03.08.434509

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