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Article

Self-assembly of protein fibrils into suprafibrillar aggregates: bridging the nano- and mesoscale.

ACS nano - 24 Jun 2014

Semerdzhiev Slav A, Dekker Dirk R, Subramaniam Vinod, Claessens Mireille M A E

Abstract excerpt

We report on in vitro self-assembly of nanometer-sized α-synuclein amyloid fibrils into well-defined micrometer-sized suprafibrillar aggregates with sheet-like or cylindrical morphology depending on the ionic strength of the solution. The cylindrical suprafibrillar structures are heavily hydrated, suggesting swollen gel-like particles. In contrast to higher order structures formed by other negatively charged...

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Identifiers

PMID: 24805840
DOI: 10.1021/nn406309c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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