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Estimating the <i>cis</i> -heritability of gene expression using single cell expression profiles controls false positive rate of eGene detection

2025-02-28

Abstract excerpt

For gene expression traits, cis -genetic heritability can quantify the strength of genetic regulation in particular cell types, elucidating the cell-type-specificity of disease variants and genes. To estimate gene expression heritability, standard models require a single gene expression value per individual, forcing data from single cell RNA-sequencing (scRNA-seq) experiments to be “pseudobulked”. Here, we show t...

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Literature Corpus work
696e64b3-04f4-5f6a-ae18-2e4cdbce661c
DOI
10.1101/2025.02.24.639892
Open publication

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Estimating the <i>cis</i> -heritability of gene expression using single cell expression profiles controls false positive rate of eGene detectionDOI 10.1101/2025.02.24.639892
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