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Article

Identifying Single-Cell Expression Quantitative Trait Loci Using a Bootstrap Penalized Hurdle Model.

Genes - 29 May 2026

Wu Dongyuan, Datta Susmita

Abstract excerpt

BACKGROUND: Expression quantitative trait loci (eQTL) analysis links genetic variants to gene expression levels, helping to uncover how genetic variation contributes to gene regulation. While traditional eQTL analyses rely on bulk RNA-seq data, recent advances in single-cell RNA sequencing (scRNA-seq) have made it possible to detect cell-type-specific eQTLs. However, the inherent sparsity and heterogeneity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42353785
DOI: 10.3390/genes17060625
PMCID: PMC13299111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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