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Article

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.

Cell - 22 Aug 2003

Harvey Kieran F, Pfleger Cathie M, Hariharan Iswar K

Abstract excerpt

Establishing and maintaining homeostasis is critical to the well-being of an organism and is determined by the balance of cell proliferation and death. Two genes that function together to regulate growth, proliferation, and apoptosis in Drosophila are warts (wts), encoding a serine/threonine kinase, and salvador (sav), encoding a WW domain containing Wts-interacting protein. However, the mechanisms by which sav...

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Source

Identifiers

PMID: 12941274
DOI: 10.1016/s0092-8674(03)00557-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.PMID 12941274Read ↗

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.Semantic proximity Read ↗

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Semantic proximity Read ↗

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.Semantic proximity Read ↗

The role of the Hippo pathway in human disease and tumorigenesisSemantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

Coupling cell growth, proliferation, and death. Hippo weighs in.Semantic proximity Read ↗

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats.Semantic proximity Read ↗

The Drosophila RASSF homolog antagonizes the hippo pathway.Semantic proximity Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway.Semantic proximity Read ↗

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.Semantic proximity Read ↗

Hippo signaling in Drosophila: recent advances and insights.Semantic proximity Read ↗

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