Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK.

PloS one - 3 Nov 2009

Geuking Peter, Narasimamurthy Rajesh, Lemaitre Bruno, Basler Konrad, Leulier François

Abstract excerpt

BACKGROUND: The JNK pathway is a mitogen-activated protein (MAP) kinase pathway involved in the regulation of numerous physiological processes during development and in response to environmental stress. JNK activity is controlled by two MAPK kinases (MAPKK), Mkk4 and Mkk7. Mkk7 plays a prominent role upon Tumor Necrosis Factor (TNF) stimulation. Eiger, the unique TNF-superfamily ligand in Drosophila, potently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crosses, Genetic
Share to Drosophila melanogaster
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Inflammation

Share to MAP Kinase Kinase 4

Share to MAP Kinase Kinase Kinases

Share to Photoreceptor Cells, Invertebrate

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 19888449
DOI: 10.1371/journal.pone.0007709
PMCID: PMC2766050

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK.PMID 19888449Read ↗

The role of the Drosophila TAK homologue dTAK during development.Semantic proximity Read ↗

Dissecting JNK signaling, one KKKinase at a time.Semantic proximity Read ↗

Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways.Semantic proximity Read ↗

Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway.Semantic proximity Read ↗

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.Semantic proximity Read ↗

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.Semantic proximity Read ↗

Molecular identification and functional characterization of a Drosophila dual-specificity phosphatase DMKP-4 which is involved in PGN-induced activation of the JNK pathway.Semantic proximity Read ↗

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.Semantic proximity Read ↗

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious DiseasesSemantic proximity Read ↗

dSTK10 maintains tissue homeostasis by preventing JNK-mediated apoptosisSemantic proximity Read ↗

Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi.Semantic proximity Read ↗

The Kinase IKKβ Regulates a STING-and NF-κB-Dependent Antiviral Response Pathway in DrosophilaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.