Article

Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity

2020-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Human coronaviruses OC43 and HKU1 are respiratory pathogen of zoonotic origin that have gained worldwide distribution. OC43 apparently emerged from a bovine coronavirus (BCoV) spill-over. All three viruses attach to 9- O -acetylated sialoglycans via spike protein S with hemagglutinin-esterase HE acting as a receptor-destroying enzyme. In BCoV, an HE lectin domain promotes esterase activity towa...

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Literature Corpus work: 696783c2-f7fb-5738-aec1-d21191f9c0dc
DOI: 10.1101/2020.04.03.003699

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