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Recent Emergence of Bovine Coronavirus Variants with Mutations in the Hemagglutinin-Esterase Receptor Binding Domain in U.S. Cattle.

Viruses - 27 Sept 2022

Workman Aspen M, McDaneld Tara G, Harhay Gregory P, Das Subha, Loy John Dustin, Hause Benjamin M

Abstract excerpt

Bovine coronavirus (BCoV) has spilled over to many species, including humans, where the host range variant coronavirus OC43 is endemic. The balance of the opposing activities of the surface spike (S) and hemagglutinin-esterase (HE) glycoproteins controls BCoV avidity, which is critical for interspecies transmission and host adaptation. Here, 78 genomes were sequenced directly from clinical samples collected...

Topics

Humans
Cattle
Animals
Coronavirus, Bovine
Hemagglutinins
N-Acetylneuraminic Acid
Coronavirus Infections
Mutation
Cattle Diseases
Glycoproteins
Esterases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleotides

Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 36298681
DOI: 10.3390/v14102125
PMCID: PMC9607061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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