Article
Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity.
Cell host & microbe - 8 Mar 2017
Bakkers Mark J G, Lang Yifei, Feitsma Louris J, Hulswit Ruben J G, de Poot Stefanie A H, van Vliet Arno L W, Margine Irina, de Groot-Mijnes Jolanda D F, van Kuppeveld Frank J M, Langereis Martijn A, Huizinga Eric G, de Groot Raoul J
Abstract excerpt
Human beta1-coronavirus (β1CoV) OC43 emerged relatively recently through a single zoonotic introduction. Like related animal β1CoVs, OC43 uses 9-O-acetylated sialic acid as receptor determinant. β1CoV receptor binding is typically controlled by attachment/fusion spike protein S and receptor-binding/receptor-destroying hemagglutinin-esterase protein HE. We show that following OC43's introduction into humans,...
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