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Structural Basis for Sarbecovirus Rc-o319 Spike Adaptation to <i>Rhinolophus cornutus</i> Bat ACE2 and Constraints on Switching to Human ACE2

2025-09-17

Abstract excerpt

Bat sarbecoviruses often exhibit species-dependent ACE2 specificity. Understanding the determinants of receptor specificity enables better assessment of the cross-species transmission potential of sarbecoviruses. Here, we characterize the S-protein of Rc-o319, a sarbecovirus identified in Japanese Rhinolophus cornutus bats. Featuring an unusual 9-amino-acid deletion within its receptor binding motif (RBM), Rc-o31...

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Literature Corpus work
0ed6c3f6-dea3-5f79-90d0-947a55d9de89
DOI
10.1101/2025.09.17.676762
Open publication

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Structural Basis for Sarbecovirus Rc-o319 Spike Adaptation to <i>Rhinolophus cornutus</i> Bat ACE2 and Constraints on Switching to Human ACE2DOI 10.1101/2025.09.17.676762
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