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Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2020

Lang Yifei, Li Wentao, Li Zeshi, Koerhuis Danielle, van den Burg Arthur C S, Rozemuller Erik, Bosch Berend-Jan, van Kuppeveld Frank J M, Boons Geert-Jan, Huizinga Eric G, van der Schaar Hilde M, de Groot Raoul J

Abstract excerpt

Human coronaviruses OC43 and HKU1 are respiratory pathogens of zoonotic origin that have gained worldwide distribution. OC43 apparently emerged from a bovine coronavirus (BCoV) spillover. All three viruses attach to 9-O-acetylated sialoglycans via spike protein S with hemagglutinin-esterase (HE) acting as a receptor-destroying enzyme. In BCoV, an HE lectin domain promotes esterase activity toward clustered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32994342
DOI: 10.1073/pnas.2006299117
PMCID: PMC7568303

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