Article
Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2016
Bakkers Mark J G, Zeng Qinghong, Feitsma Louris J, Hulswit Ruben J G, Li Zeshi, Westerbeke Aniek, van Kuppeveld Frank J M, Boons Geert-Jan, Langereis Martijn A, Huizinga Eric G, de Groot Raoul J
Abstract excerpt
Hemagglutinin-esterases (HEs) are bimodular envelope proteins of orthomyxoviruses, toroviruses, and coronaviruses with a carbohydrate-binding "lectin" domain appended to a receptor-destroying sialate-O-acetylesterase ("esterase"). In concert, these domains facilitate dynamic virion attachment to cell-surface sialoglycans. Most HEs (type I) target 9-O-acetylated sialic acids (9-O-Ac-Sias), but one group of...
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