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Molecular Surveillance of Coronaviruses in Riyadh (2025-2026): Persistent Genotype C and Conserved N-Glycosylation Motifs in Human Coronavirus OC43.

International journal of molecular sciences - 10 Apr 2026

Alrezaihi Abdulrahman F, Aziz Ibrahim M, Farrag Mohamed A, Aldakheel Fahad M, Almuqrin Abdulaziz M, Alzamil Lama, Alanazi Fuad, Aljowaie Reem M, Almajhdi Fahad N

Abstract excerpt

Seasonal human coronaviruses (HCoVs) continue to undergo adaptive evolution under structural and immune-mediated constraints. We investigated the molecular epidemiology and spike (S) protein structural variation of circulating coronaviruses in Riyadh, Saudi Arabia, during the 2025-2026 winter season, with particular emphasis on genotype persistence and glycosylation architecture in HCoV-OC43. Among 293...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42074062
DOI: 10.3390/ijms27083418
PMCID: PMC13116566

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