Article

Bovine coronavirus evolution preserves spike architecture while remodeling key functional regions

2026-08-05

Abstract excerpt

Bovine coronavirus (BCoV) is a major pathogen of cattle and the closest known ancestor of the human coronavirus OC43, yet how viral evolution reshapes spike protein structure and function remains poorly understood. Here, we combined comparative genomics, glycoproteomics, cryo-EM, and antigenic characterization to define the structural mechanisms underlying spike evolution across representative BCoV lineages. We id...

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Literature Corpus work: 371fe563-1dc0-5522-81e1-ae6e3c603021
DOI: 10.64898/2026.08.05.743018

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