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Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes

25 May 2022

Abstract excerpt

Abstract Human coronavirus OC43 is a globally circulating common cold virus sustained by recurrent reinfections. How it persists in the population and defies existing herd immunity is unknown. Here we focus on viral glycoprotein S, the target for neutralizing antibodies, and provide an in-depth analysis of its antigenic structure. Neutralizing antibodies are directed to the sialoglycan-receptor binding site in...

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PMID: 35614127
DOI: 10.1038/s41467-022-30658-0

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