Article

Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

2022-05-03

Abstract excerpt

<title>Abstract</title> <p>Topoisomerase IIIα (TOP3A) belongs to the conserved Type IA family of DNA topoisomerases. Here we report that TOP3A is associated with DNA replication as well as a TOP3A "self-trapping" mutant (TOP3A- R364W) that generates TOP3A DNA cleavage complexes (TOP3Accs) in human cells. We show that trapped TOP3Accs interfere with replication, induce DNA damage and genome instability. To elucida...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69677c1a-4acc-5485-ae47-15da3d29ded6
DOI: 10.21203/rs.3.rs-1570399/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Replication-associated formation and repair of human topoisomerase IIIα cleavage complexesDOI 10.21203/rs.3.rs-1570399/v1Read

Replication-associated formation and repair of human topoisomerase IIIα cleavage complexesSemantic proximity Read

TOP3A coupling with replication forks and repair of TOP3A cleavage complexesSemantic proximity Read

Human topoisomerases and their roles in genome stability and organizationSemantic proximity Read

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.Semantic proximity Read

Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN ProteaseSemantic proximity Read

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA-protein crosslinks <i>in vivo</i>Semantic proximity Read

Topoisomerase 3B (TOP3B) DNA and RNA Cleavage Complexes and Pathway to Repair TOP3B-linked RNA and DNA BreaksSemantic proximity Read

Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexesSemantic proximity Read

GCNA preserves genome integrity and fertility across speciesSemantic proximity Read

SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.Semantic proximity Read

Genome Instability Induced by Topoisomerase Misfunction.Semantic proximity Read

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesisSemantic proximity Read