Article

RNA-mediated double-strand break repair in human cells

2022-11-01

Abstract excerpt

<h4>Summary</h4> Double-strand breaks (DSBs) in DNA are challenging lesions to repair. Human cells employ at least three DSB repair mechanisms, with a preference for non-homologous end joining (NHEJ) over homologous recombination (HR) and microhomology-mediated end joining (MMEJ) 1,2 . In contrast to HR, NHEJ and MMEJ do not utilize a DNA template molecule to recover damaged and/or lost nucleotides 2 . NHEJ dir...

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Literature Corpus work: 52b62d1f-8f27-5027-ad8c-d7f440ffe954
DOI: 10.1101/2022.11.01.514688

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