Article

CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway

2022-01-14

Abstract excerpt

The RNA world is changing our views about sensing and resolution of DNA damage. Here, we developed single-molecule DNA/RNA analysis approaches to visualize how nascent RNA facilitates the repair of DNA double-strand breaks (DSBs). RNA polymerase II (RNAPII) is crucial for DSB resolution in human cells. DSB-flanking, RNAPII-generated nascent RNA forms RNA:DNA hybrids, guiding the upstream DNA repair steps towards f...

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Literature Corpus work: 46db2794-d6d5-5f87-bd89-17a203da9761
DOI: 10.1101/2022.01.14.476291

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