Article
DNA lesions can frequently precede DNA:RNA hybrid accumulation.
Nature communications - 10 Mar 2025
Mangione Raphaël M, Pierce Steven, Zheng Myriam, Martin Robert M, Goncalves Coralie, Kumar Arun, Scaglione Sarah, de Sousa Morgado Cristiana, Penzo Arianna, Lancrey Astrid, Reid Robert J D, Lautier Ophélie, Gaillard Pierre-Henri, Stirling Peter C, de Almeida Sérgio F, Rothstein Rodney, Palancade Benoit
Abstract excerpt
While DNA:RNA hybrids contribute to multiple genomic transactions, their unscheduled formation is a recognized source of DNA lesions. Here, through a suite of systematic screens, we rather observed that a wide range of yeast mutant situations primarily triggering DNA damage actually leads to hybrid accumulation. Focusing on Okazaki fragment processing, we establish that genic hybrids can actually form as a...
Read the complete abstract on PubMedTopics
- Saccharomyces cerevisiae
- Humans
- DNA Damage
- RNA
- DNA Replication