Article
Molecular characterization of the histopathological growth patterns of colorectal cancer liver metastases by RNA sequencing of targeted samples at the tumor-liver interface.
Clinical & experimental metastasis - 12 Dec 2024
Latacz Emily, Verheul Sanne M L, Sillis Yasmine, van Dam Pieter-Jan, Doukas Michail, Grunhagen Dirk J, Nyström Hanna, Dirix Piet, Dirix Luc, Van Laere Steven, Verhoef Cornelis, Vermeulen Peter
Abstract excerpt
The behaviour of metastases in patients with liver-metastatic colorectal cancer (CRC) is still not adequately considered during treatment planning. However, studies in large cohorts have shown that the disease course in these patients depends on the histopathological growth pattern (HGP) of the liver metastases, with the desmoplastic (or encapsulated) pattern responsible for a favourable outcome and the...
Topics
- Humans
- Colorectal Neoplasms
- Liver Neoplasms
- Female
- Male
- Sequence Analysis, RNA
- Prospective Studies
- Middle Aged
- Transcriptome
- Aged