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Article

Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites

20 Mar 2015

Abstract excerpt

BACKGROUND AND OBJECTIVE: Systemic therapy for metastatic cancer is currently determined exclusively by the site of tumor origin. Yet, there is increasing evidence that the molecular characteristics of metastases significantly differ from the primary tumor. We define the evolutionary dynamics of metastases that govern this molecular divergence and examine their potential contribution to variations in response to...

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PMID: 25794501
DOI: 10.1093/emph/eov006

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