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HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice.

Cell death & disease - 14 May 2024

Chen Laiqiang, Qin Yiyang, Guo Tingting, Zhu Wenzhen, Lin Jingpan, Xing Tingting, Duan Xuezhi, Zhang Yiran, Ruan Eshu, Li Xiang, Yin Peng, Li Shihua, Li Xiao-Jiang, Yang Su

Abstract excerpt

Huntington's disease (HD) is a monogenic neurodegenerative disease, caused by the CAG trinucleotide repeat expansion in exon 1 of the Huntingtin (HTT) gene. The HTT gene encodes a large protein known to interact with many proteins. Huntingtin-associated protein 40 (HAP40) is one that shows high binding affinity with HTT and functions to maintain HTT conformation in vitro. However, the potential role of HAP40 in...

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Identifiers

PMID: 38744826
DOI: 10.1038/s41419-024-06716-4
PMCID: PMC11094052

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