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Article

The Biology of Huntingtin.

Neuron - 2 Mar 2016

Saudou Frédéric, Humbert Sandrine

Abstract excerpt

Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). The gene encoding huntingtin, HTT, and its dominantly inherited mutation were identified more than 20 years ago. Subsequently, in the hope of finding a cure for HD, there has been intense research aimed at...

Topics

Animals
Biology
Humans
Huntingtin Protein
Huntington Disease
Mutation
Nerve Tissue Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26938440
DOI: 10.1016/j.neuron.2016.02.003

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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