Article

Effects of polygenic risk score communication on health outcomes: systematic review and meta-analysis

2025-11-06

Abstract excerpt

<h4>Objective</h4> The purpose of this systematic review and meta-analysis is to summarize evidence from all RCTs to-date on the efficacy of polygenic risk score (PRS) communication in changing health outcomes. <h4>Design</h4> Systematic review and meta-analysis. <h4>Data sources</h4> Cochrane Central Register of Controlled Trials (CENTRAL) and Pubmed, from inception to March 2025. <h4>Study selection</h4> Ran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6916e6a9-dea5-5c7c-8c3c-3ec1bb43d1a3
DOI: 10.1101/2025.11.04.25339466

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of polygenic risk score communication on health outcomes: systematic review and meta-analysisDOI 10.1101/2025.11.04.25339466Read

Effect of disclosing a polygenic risk score for coronary heart disease on adverse cardiovascular events: 10-year follow-up of the MI-GENES randomized clinical trialSemantic proximity Read

Communicating polygenic and non-genetic risk for atherosclerotic cardiovascular disease - An observational follow-up studySemantic proximity Read

Advancing the communication of genetic risk for cardiometabolic diseases: A critical interpretive synthesisSemantic proximity Read

Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefitSemantic proximity Read

Polygenic Risk Score Implementation into Clinical Practice for Primary Prevention of Cardiometabolic Disease.Semantic proximity Read

Evaluating the impact of communicating high polygenic risk for coronary artery disease on the health behaviour of young overweight adults: a pragmatic randomised controlled trial.Semantic proximity Read

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.Semantic proximity Read

Polygenic risk scores in the clinic: a systematic review of stakeholders' perspectives, attitudes, and experiences.Semantic proximity Read

Challenges in clinical translation of polygenic risk score analyses: A systematic review.Semantic proximity Read

The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis.Semantic proximity Read

Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.Semantic proximity Read

Session Introduction: SALUD: Scalable Applications of cLinical risk Utility and preDiction.Semantic proximity Read