Evaluating the impact of communicating high polygenic risk for coronary artery disease on the health behaviour of young overweight adults: a pragmatic randomised controlled trial.

Abstract excerpt

Around 50% of the variation in cardiovascular disease (CVD) risk is attributable to heritable factors, and polygenic risk scores (PRS) can now capture part of that genetic component. As personalised public health advances, polygenic risk scores (PRS) may offer a useful tool for conveying overall CVD risk, particularly in younger populations, but require evaluation in real-world clinical trials. This study...

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