Article
Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms.
Cell stem cell - 4 Mar 2021
Tong Jingyuan, Sun Ting, Ma Shihui, Zhao Yanhong, Ju Mankai, Gao Yuchen, Zhu Ping, Tan Puwen, Fu Rongfeng, Zhang Anqi, Wang Ding, Wang Di, Xiao Zhijian, Zhou Jiaxi, Yang Renchi, Loughran Stephen J, Li Juan, Green Anthony R, Bresnick Emery H, Wang Dong, Cheng Tao, Zhang Lei, Shi Lihong
Abstract excerpt
The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F+ myeloproliferative neoplasms (MPNs), harboring the same mutation in hematopoietic stem cells (HSCs), display diverse phenotypes, including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). These chronic malignant disorders are ideal models to analyze the...
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