Article

The development of a hiPSC-based platform to identify tissue-dependencies of IDH1 R132H

2023-08-23

Abstract excerpt

<title>Abstract</title> <p>Hotspot mutations in the DNA encoding for the R132 codon of the enzyme isocitrate dehydrogenase 1 (IDH1) is a common molecular feature of different tumors. The oncogenic potential of IDH1R132 and its clinical prognostic value however, varies strongly between tumors of different tissues. Technologies to conduct functional investigations of isogentic controlled IDH1R132 in dependency of d...

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Literature Corpus work: 690a9a2b-f74f-5034-8d6c-62b14a04f39a
DOI: 10.21203/rs.3.rs-3216060/v1

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