Article
Immunohistochemical analysis of 1844 human epithelial and haematopoietic tumours and sarcomas for IDH1R132H mutation.
Histopathology - 1 Jun 2011
Sahm Felix, Capper David, Meyer Jochen, Hartmann Christian, Herpel Esther, Andrulis Mindaugas, Mechtersheimer Gunhild, Petersen Iver, Paulus Werner, von Deimling Andreas
Abstract excerpt
AIMS: Mutations in the isocitrate dehydrogenase 1 gene have been identified recently to play a key role in diffuse astrocytoma and oligodendroglioma as well as in acute myeloid leukaemia. In glioma, IDH1R132H is the most common mutation type, which is associated with younger patient age and longer patient survival compared to wild-type status. Sequencing analyses of carcinomas and lymphomas have detected IDH1...
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