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Article

Generation of induced neural stem cells with inducible IDH1R132H for analysis of glioma development and drug testing.

PloS one - 1 Jan 2020

Rosiak-Stec Kamila, Grot Dagmara, Rieske Piotr

Abstract excerpt

Mutation in isocitrate dehydrogenase 1 (IDH1R132H) occurs in various types of cancer, including low and high grade gliomas. Despite high incidence indicating its central role in tumor initiation and progression there are no targeted therapies directed against this oncogene available in the clinic. This is due to the limited understanding of the role of IDH1R132H in carcinogenesis, which is further propagated by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32946483
DOI: 10.1371/journal.pone.0239325
PMCID: PMC7500637

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