Article

Localized Chemogenetic Silencing of Inhibitory Neurons: A novel Mouse Model of Focal Cortical Seizures

2020-11-05

Abstract excerpt

Focal cortical epilepsies are frequently refractory to available anticonvulsant drug therapies. One key factor contributing to this state is the limited availability of animal models that allow to reliably study focal cortical seizures and how they recruit surrounding brain areas in-vivo . In this study, we selectively expressed the inhibitory chemogenetic receptor, hM4D, in GABAergic neurons in focal cortical ar...

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Literature Corpus work: f3c56dd5-692f-5afc-82ea-ddd9f4a37488
DOI: 10.1101/2020.11.04.367862

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