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Whole brain fluorescence imaging in <i>Drosophila</i> reveals spreading depression and its initiation, propagation, and resilience dynamics

2025-10-10

Abstract excerpt

Spreading depression (SD) is a wave of neuronal hyperactivity followed by depolarization block that propagates through large brain regions and is associated with disorders such as migraine, stroke, and brain injury. The mechanisms that initiate SD and alter susceptibility to it remain incompletely understood. Here, we use whole-brain fluorescence imaging with genetically encoded pan-neuronal calcium and voltage se...

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Literature Corpus work
ba2c9dce-32b8-52e2-9a55-5df2b5c01a8d
DOI
10.1101/2025.10.09.681455
Open publication

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Whole brain fluorescence imaging in <i>Drosophila</i> reveals spreading depression and its initiation, propagation, and resilience dynamicsDOI 10.1101/2025.10.09.681455
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