Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Ets2 super-enhancer modulates endothelial-mesenchymal transition during cardiac ageing.

Cardiovascular research - 14 Feb 2026

Guo Zhenglong, Li Lan, Luo Junwei, Xue Wei, Bian Shasha, Zhu Yongchang, Huo Dawei, Yang Wenke, Ma Jing, Hao Yibin, Fan Guanwei, Hao Bingtao, Liao Shixiu

Abstract excerpt

AIMS: Cardiac ageing is characterized by endothelial dysfunction and associated cardiovascular pathologies, often involving endothelial-to-mesenchymal transition (EndoMT) in cardiac endothelial cells. While the transcription factor Ets2, a member of the Ets family, is known to regulate endothelial cell survival and function, its role in EndoMT and cardiac ageing remains poorly understood. METHODS AND RESULTS: To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Epithelial-Mesenchymal Transition

Share to Fibrosis

Share to Myocardial Infarction

Share to Myocardium

Share to Ventricular Remodeling

Source

Identifiers

PMID: 41253710
DOI: 10.1093/cvr/cvaf242

Genes

TIE1
ETS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ets2 super-enhancer modulates endothelial-mesenchymal transition during cardiac ageing.PMID 41253710Read ↗

EndoAge Atlas: Non-linear dynamics of endothelial aging reveal organ-specific vascular trajectories in miceSemantic proximity Read ↗

Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosisSemantic proximity Read ↗

The PNUTS-PP1 axis regulates endothelial aging and barrier function via SEMA3B suppressionSemantic proximity Read ↗

Endothelial expression of ZBTB16 protects against cardiac agingSemantic proximity Read ↗

Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysisSemantic proximity Read ↗

Stress-responsive enhancer RNAs couple chromatin reprogramming to post-transcriptional control of senescenceSemantic proximity Read ↗

Age-dependent transcriptional alterations in cardiac endothelial cellsSemantic proximity Read ↗

Epigenetic Regulation of Endothelial-to-Mesenchymal Transition in Chronic Heart DiseaseSemantic proximity Read ↗

MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular DiseaseSemantic proximity Read ↗

The dual functionality of EZH2 in cardiovascular disease: Bridging cancer biology and cardiac pathophysiology through epigenetic regulation, metabolic reprogramming, and novel therapeutic interventionsSemantic proximity Read ↗

The aging-induced long non-coding RNA <i>MIRIAL</i> controls endothelial cell and mitochondrial functionSemantic proximity Read ↗

Single-Cell RNA Sequencing and Assay for Transposase-Accessible Chromatin Using Sequencing Reveals Cellular and Molecular Dynamics of Aortic Aging in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.