SIRT1 remodels astrocyte metabolism and promotes viral replication during neurotropic orthoflavivirus infection

Abstract excerpt

Orthoflaviviruses depend on host metabolic resources to replicate, but how distinct cell types in the central nervous system (CNS) alter their metabolism in response to infection remains incompletely understood. Here, we examined whether the NAD+-dependent deacetylase SIRT1 is engaged during Zika virus (ZIKV) and West Nile virus (WNV) infection and whether its activity influences infection outcomes. SIRT1 activity...

Topics

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• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Cytomegalovirus and herpesvirus research
• Genomics, phytochemicals, and oxidative stress
• Mitochondrial Function and Pathology
• Mosquito-borne diseases and control
• RNA regulation and disease
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

68fe5879-1fa6-5cd5-89ab-182e439fb26b

DOI

10.64898/2026.07.23.740149